hTERT Immortalized Cells

hTERT-immortalized Cells

A breakthrough in cell biology research

Human telomerase reverse transcriptase (hTERT)–immortalized primary cells represent a breakthrough in cell biology research that combines the in vivo nature of primary cells with the traditional cell line's ability to survive continuously in vitro. ATCC genetically modified human primary cells so they exhibit the growth characteristics of a continuous cell line with extended proliferative capacity yet maintain the physiology of a primary cell.

ATCC hTERT-immortalized primary cells include:

Aortic endothelial cells
Barrett’s esophageal epithelial cells
Bronchial epithelial cells
Respiratory epithelial cells
Chrondrocyte fibroblast cells
Dermal microvascular endothelial cells (including TIME cells)
Endometrial fibroblast cells
Foreskin keratinocytes

Lung endothelial cells
Mammary epithelial cells
Mesenchymal stem cells
NTAP Schwann cells
Pancreas duct cells
Prostrate cells
Renal epithelial cells
Retinal pigmented epithelial cells
Skin fibroblast cells

hTERT-immortalized Primary Cells: You Can Have Your Cake and Eat It Too

Understanding how skin is pigmented is critical to treating pathologies such as hyperpigmentation, hypopigmentation, and mixed hyperpigmentation/hypopigmentation. Read this poster to learn how hTERT-immortalized melanocytes are a robust model for studying melanocyte function by providing primary melanocyte functionality while exhibiting immortalized characteristics.

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hTERT-immortalized and Primary Ker-CT Differentiate into Epidermal Structures

Human keratinocytes formed 3-D epidermal structures, rendering them an excellent and reproducible in vitro whole-cell model for the examination of mechanisms regulating keratinocyte biology in the processes of wound healing, dermal remodeling, cancer research, and drug toxicology evaluation in a tissue physiology-relevant context.

Read the application note