L-Methionine

SKU:
TC080M
CAS Number : 63-68-3
Molecular Formula : C₅H₁₁NO₂S
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Product Identifier

Product Code TC080M
Molecular weight 149.21
Molecular formula C5H11NO2S
CAS No. 63-68-3

Technical Specification

Appearance (USP) White crystals
Appearance (EP, BP) White or almost white crystalline powder or colourless crystals
Appearance (JP) White crystals or crystalline powder
Solubility (USP) Soluble in water, in warm dilute alcohol and in dilute mineral acids. Insoluble in ether, in absolute alcohol, in benzene and in acetone
Solubility (EP, BP) Soluble in water, very slightly soluble in ethanol (96%)
Solubility (JP) It is freely soluble in formic acid and soluble in water and very slightly soluble in ethanol (95%). It dissolves in dilute hydrochloric acid.
pH (USP) 5.60 - 6.10 (1% in water)
pH (EP, BP) 5.50 - 6.50 (2.5% in water)
pH (JP) 5.2 - 6.2 (2.5% in water)
Identification : FTIR (JP) Matches with the standard pattern
Identification A : FTIR (USP) Matches with the standard pattern
Identification A : Specific rotation (EP, BP) +22.5 to +24.0 (c = 2% in HCl R1 at 20 ± 0.5°C, dried substance)
Identification B : FTIR (EP, BP) Matches with the standard pattern
Identification C: TLC (EP, BP) The principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution
Identification D (EP, BP) A dark red colour develops
Appearance of solution (EP, BP) 2.5% solution in water is clear and colourless
Clarity & colour of solution (JP) Solution of 0.5 gm in 20 mL of 2 mol/L HCl is clear and colourless
Chloride (USP) <= 0.05%
Chloride (EP, BP) <= 0.02%
Chloride (JP) <= 0.021%
Ammonium (EP, BP, JP) <= 0.02%
Sulfate (USP) <= 0.03%
Sulfate (EP, BP) <= 0.03%
Sulfate (JP) <= 0.028%
Iron (USP) <= 0.003%
Iron (EP, BP) <= 0.001%
Sulfated ash (EP, BP) <= 0.10%
Arsenic (JP) <= 0.0002%
Related substances : TLC (JP) The spots other than the principal spot from the sample solution are not more intense than the spot from the standard solution
Related compounds, system suitability : HPLC : resolution (USP, EP, BP) >= 5.0, the resolution between the methionine and L-methionine sulfoxide peaks
Related compounds : Methionine sulfoxide : HPLC (USP) <= 0.1%
Related compounds : N-Acetyl-D,L-Methionine : HPLC (USP) <= 0.20%
Related compounds : Any unspecified impurity : HPLC (USP, EP, BP) <= 0.10%
Related compounds : Total unspecified impurities : HPLC (USP, EP, BP) <= 0.3%
Specific rotation (USP) +22.4° to +24.7° (c = 2% in 6N HCl, at 25°C)
Specific rotation (EP, BP) +22.5° to +24.0° (c = 2% in HCl R1 at 20 ± 0.5°C, dried substance)
Specific rotation (JP) +21.0° to +25.0° (c = 2% in 6M HCl at 20°C, dried substance)
Loss on drying (at 105°C, 3 hr) (USP) <= 0.3%
Loss on drying (at 105°C, 2 hr) (EP, BP) <= 0.5%
Loss on drying (at 105°C, 3 hr) (JP) <= 0.3%
Residue on ignition (USP) <= 0.40%
Residue on ignition (JP) <= 0.10%
Heavy metals (JP) <= 0.002%
Assay (NT, on dried basis) (USP) 98.50 - 101.50%
Assay (NT, on dried basis) (EP, BP) 99.00 - 101.00%
Assay (NT, on dried basis) (JP) min. 98.50%
Bacterial endotoxin <= 1 EU/mg

Storage and Shelf Life

Storage Store below 30°C away from bright light.
Shelf life 48 months.
Use before Expiry date given on the product label.
CAS Number : 63-68-3
Molecular Formula : C₅H₁₁NO₂S
More Information
Product Name L-Methionine
SKU TC080M
CAS No 63-68-3
EC No. 200-562-9
Molecular formula C₅H₁₁NO₂S
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