Hi-PCR® Colistin Resistance Probe PCR Kit

Colistin have recently regained popularity for treatment of severe infections caused by extensively drug-resistant (XDR) Gram-negative bacterial strains. As a likely consequence, emergence of Colistin resistance is being increasingly reported in the clinical setting, especially among carbapenem-resistant Klebsiella pneumoniae isolates. Acquired resistance to polymyxins is generally associated with chromosomal mutations. However, a new plasmid-mediated transferable resistance determinant, the mcr-1 gene has been described recently. PCR is an alternative method that allows for sensitive and specific detection of mcr-1 gene from clinical samples / cultured isolates. Hi-PCR® Colistin Resistance Probe PCR Kit is designed to detect mcr-1 gene with Internal Control in a single tube reaction.