Hi- Thal Kit

Thalassemia is a group of genetic disorders characterized by quantitative defects in globin chain synthesis with subsequent absence or decrease of hemoglobin production leading to variable degrees of microcytic anemia; it is commonly found in people of Mediterranean, African, Middle Eastern, Indian, Chinese or Southeast Asian origin. Beta?thalassemia is an autosomal recessive single gene disorder characterized by reduced (?+) or (?0) beta globin chain synthesis leading to reduced hemoglobin A (HbA) synthesis.This kit is based on the limit of hypotonicity that the red cell can withstand. Red Blood cells in thalassemia patients have decreased osmotic fragility as compared to red blood cells in normal individuals. When red blood cells from thalassemia patients are introduced into higher concentration solution, the cells rupture leading to turbidity of the reaction mixture. These cells have low capacity to expand in low osmotic solutions.