Tetracycline hydrochloride, Cell Culture Tested

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SKU:
TC036
CAS Number : 64-75-5
Synonym : Anhydrotetracycline, Abramycin, Biocycline, Cefracycline
Molecular Formula : C₂₂H₂₄N₂O₈·HCl


Tetracycline is a polyketide antibiotic produced by Streptomyces spp. It inhibits protein synthesis by binding to 30S ribosomal subunit and blocking attachment of charged aminoacyl tRNA to ribosome. This prevents incorporation of new amino acids to the nascent peptide chain. It acts as a broad spectrum antibiotic against Grampositive and Gram-negative bacteria.

In cell culture media, Tetracycline finds application as an anti-bacterial agent to prevent contamination. It is also used as a selection agent for cells containing tetracycline resistance gene. Besides this, Tetracyclinebased externally regulated (Tet-based) systems have been successfully used to control the expression of numerous transgenes in cultured cells. These systems work on principle of reversible switch-on-switch-off of the experimental gene in presence of Tetracycline. These are tightly regulated and highly responsive systems that produce on-demand robust expression of gene of interest in target cells. During such Tet-system based mammalian cell culture studies, an animal-free media is to be used for cell growth and to prevent any interference from excess tetracycline present in media.

CAS Number : 64-75-5
Synonym : Anhydrotetracycline, Abramycin, Biocycline, Cefracycline
Molecular Formula : C₂₂H₂₄N₂O₈·HCl
More Information
Product Name Tetracycline hydrochloride, Cell Culture Tested
SKU TC036
CAS No 64-75-5
Molecular formula C₂₂H₂₄N₂O₈·HCl
Molecular Weight 480.9
Synonym Anhydrotetracycline, Abramycin, Biocycline, Cefracycline
Storage Store powder at 2 - 8°C in air tight containers and away from bright light.
Shelf Life 3 Years
Customized Product Available No
Appearance Light yellow to orange crystals or powder or solid
Solubility 33.3 mg soluble in 1 ml of water on heating
pH 1.80 - 2.80
FTIR Matches with standard pattern
Specific Rotation -255° to -240° (c = 0.50% in 0.1M HCl at 20°C)
Antibiotic Sensitivity Complies
Potency NLT 900 μg/mg
Assay (NT/HPLC/NaOH Titration) 90.00 - 102.00%
Cell Culture Test Passes
UN No. 3077
Class 9
Packing Group III
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