Plot No. C40, Road No. 21Y, MIDC, Wagle Industrial Estate, Thane(W)-400604, MH, India
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(-)-Riboflavin
SKU:
TC167M
CAS Number :
83-88-5
Molecular Formula :
C₁₇H₂₀N₄O₆
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Chemicals Meeting Pharmacopoeial Testing Specifications#ff0000
Product Identifier
| Product Code | TC167M |
|---|---|
| Molecular weight | 376.36 |
| Molecular formula | C17H20N4O6 |
| CAS No. | 83-88-5 |
Technical Specification
| Appearance (EP, BP) | Yellow to orange-yellow crystalline powder |
|---|---|
| Appearance (JP) | Yellow to orange-yellow crystals |
| Appearance (USP) | Yellow to orange-yellow crystalline powder |
| Appearance (IP) | Yellow to orange-yellow crystalline powder |
| Solubility (EP, BP) | Very slightly soluble in water, practically insoluble in ethanol (96%) |
| Solubility (USP) | Soluble in dilute solution of alkalies; very slightly soluble in water, in alcohol, and in isotonic sodium chloride solution; insoluble in ether and in chloroform |
| Solubility (JP) | Very slightly soluble in water, practically insoluble in ethanol (95%), in acetic acid (100), and in diethyl ether. It dissolves in sodium hydroxide TS |
| Solubility (IP) | Very slightly soluble in water, more soluble in saline solution than in water; practically insoluble in chloroform, in ethanol (95%) and in ether. |
| Identification A: Colour and fluorescence of solution (USP) | The sample solution is pale greenish yellow by transmitted light. By reflected light, it exibits an intense yellowish green fluorescence that disappears upon the addition of mineral acids and alkalies |
| Identification A: Specific optical rotation (EP, BP) | -135.00° to -115.00° (c = 0.50% in 0.05M NaOH, at 20 ± 0.5°C, dried substance, measure the rotation within 30 min. of dissolution) |
| Identification A : FTIR (IP) | Matches with the standard pattern |
| Identification B : TLC (EP, BP) | The principal spot in the chromatogram obtained with the test solution is similar in position and size to the principal spot in the chromatogram obtained with the reference solution. |
| Identification B (IP) | A pale greenish yellow colour by transmitted light and an intense yellowish green fluorescence by reflected light, which disappears on addition of mineral acids or alkalis |
| Identification C (EP, BP) | The solution has, by transmitted light, a pale greenish yellow colour, and, by reflected light, an intense yellowish-green fluorescence which disappears on the addition of mineral acids or alkalis. |
| Identification 1 (JP) | The fluorescence disappears upon the addition of dilute hydrochloric acid or sodium hydroxide TS |
| Identification 2 (JP) | The chloroform layer shows a yellow-green fluorescence. |
| Identification 3 (JP) | Both spectra exhibit similar intensities of absorption at the same wavelengths. |
| Melting point (JP) | about 290°C (with decompositions) |
| pH (Saturated aqueous solution) : (IP) | 5.50 - 7.20 |
| Specific rotation (USP, IP) | -135.00° to -115.00° (c = 0.50% in 0.05M NaOH, measure the rotation within 30 min. of dissolution, use dry substance) |
| Specific rotation (EP, BP) | -135.00° to -115.00° (c = 0.50% in 0.05M NaOH, at 20 ± 0.5°C, dried substance, measure the rotation within 30 min. of dissolution) |
| Optical rotation (JP) | -142.00° to -128.00° (c = 0.50% at 20°C, 0.1 g of dried Riboflavin, dissolve in 4 mL of dilute NaOH TS, add 10 mL water, add 4 mL of aldehyde-free ethanol and dilute with water to make 20 mL, measure the rotation within 30 min. after preparing the solution) |
| Light Absorbance 1 at A373/A267 : (IP) | 0.31 to 0.33 |
| Absorbance ratio 1 at A373/A267 : (EP, BP) | 0.31 to 0.33 |
| Light Absorbance 2 at A444/A267 : (IP) | 0.36 to 0.39 |
| Absorbance ratio 2 at A444/A267: (EP, BP) | 0.36 to 0.39 |
| Related substance, system suitability, HPLC: Resolution (EP, BP) | >= 5.0 between the peak due to impurity A and B in the chromatogram obtained with reference solution (C) |
| Related substances 1: Impurity A : HPLC (EP, BP) | <= 0.025% |
| Related substances 2: Impurities B, C, D for each impurity: HPLC (EP, BP) | <= 0.20% |
| Related substances 3: Unspecified impurities for each impurity: HPLC (EP, BP) | <= 0.10% |
| Related substances 4: Total impurities: HPLC (EP, BP) | <= 0.50% |
| Loss on drying (at 105°C, 2h) : (USP, EP, BP, JP, IP) | <= 1.50% |
| Residue on ignition (USP) | <= 0.30% |
| Residue on ignition (JP) | <= 0.20% |
| Sulfated ash (EP, BP, IP) | <= 0.10% |
| Limit of Lumiflavin (by UV, USP) | <= 0.025 |
| Lumiflavin (JP) | The filtrate has no more color than the control solution. (Control solution: To 2.0 mL of 1/60 mol/L potassium dichromate VS add water to make 1000 mL.) |
| Lumiflavin (IP) | The filtrate is not more intensely colored than reference solution BYS6 |
| Assay (UV, on dry basis) : (JP) | min. 98.00% |
| Assay (UV, on dry basis) : (USP) | 98.00 - 102.00% |
| Assay (UV, on dry basis) : (EP, BP) | 97.00 - 103.00% |
| Assay (UV, dried basis) : (IP) | 98.00 - 101.00% |
Storage Information
| Storage | Store below 30°C away from bright light. |
|---|---|
| Shelf life | 36 months. Use before expiry date given on the product label. |
CAS Number :
83-88-5
Molecular Formula :
C₁₇H₂₀N₄O₆
| Product Name | (-)-Riboflavin |
|---|---|
| SKU | TC167M |
| CAS No | 83-88-5 |
| EC No. | 201-507-1 |
| Molecular formula | C₁₇H₂₀N₄O₆ |
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