Colorless, transparent crystals, or white, granular crystalline powder, or white flakes
Appearance (EP, BP)
White or almost white, crystalline powder or colourless crystals
Appearance (JP, IP)
Colorless crystals or a white crystalline powder.
Solubility (USP)
Very soluble in water, soluble in alcohol
Solubility (EP, BP)
Very soluble in water, soluble in ethanol (96%)
Solubility (JP)
Very soluble in water, freely soluble in acetic acid (100%), soluble in ethanol (95%), and practically insoluble in diethyl ether
Solubility (IP)
Very soluble in water, soluble in ethanol (95%)
Identification A : Sodium (USP)
Meets the requirements
Identification: Acetate and sodium salt (JP)
10% solution in water responds to the qualitative test for acetate and sodium salt
Identification : (IP)
1 mL of 10% solution in water gives reaction (B) of acetate and reaction (A) of sodium salts
Identification A : Acetate (EP, BP)
1 mL of 10% solution gives reaction (b)of acetate
Identification B: Sodium (EP, BP)
1 mL of 10% solution gives reaction (a) of sodium
Identification B: Acetate (USP)
Meets the requirements in test A
Identification C: Loss on drying (EP, BP)
39.00 - 40.50% (at 130°C to constant weight)
pH (3% in water) : (USP)
7.50 - 9.20
pH (5% in water) : (EP, BP, IP)
7.50 - 9.00
Appearance of solution (EP, BP, IP)
10% solution in water is clear and colorless
Clarity and color of solution (JP)
10% solution in water is clear and colorless
Acidity or alkalinity (JP)
In the 5% solution add 3 drops of phenolphthalein TS : a red color develops or 1.0 mL of 0.01M HCl is added after cooling to 10°C : the red colour disappears
Chloride (EP, BP)
<= 0.02%
Chloride (JP)
<= 0.011%
Chloride (USP)
<= 0.035%
Chloride (IP)
<= 0.025%
Sulfates (EP, BP, IP)
<= 0.02%
Sulfate (JP)
<= 0.017%
Sulfate (USP)
<= 0.005%
Insoluble matter (USP)
<= 0.05%
Heavy metals (JP)
<= 0.0010%
Heavy metals (IP)
<= 0.00010%
Calcium and magnesium (USP)
No turbidity is produced within 5 min.
Calcium and magnesium (EP, BP, IP)
<= 0.0050% as Ca
Calcium and magnesium (JP)
Complies
Arsenic (EP, BP, JP, IP)
<= 0.0002%
Aluminium (IP)
<= 0.00002%
Iron (EP, BP)
<= 0.0010%
Iron (IP)
<= 0.0020%
Reducing substances (IP)
The pink color is not completely discharged
Reducing substances (EP, BP)
The pink colour persists for at least 1 hr
Potassium (USP)
No precipitate is formed
Potassium permanganate - reducing substance (JP)
The red color of the solution does not disappear
Loss on drying (JP)
39.00 - 45.50% (at 80°C for 2 hr, then at 130°C for 2 hr)