Sphingomyelin

Product Identifier

Directions:

Preparation instructions:
The working concentration of sphingomyelin will depend on its application. Solutions can be prepared in ethanol, acetic acid or chloroform. Prepared solutions can be sterilized by filtering through a sterile membrane filter with a porosity of 0.22micron or less.

Technical Specification

Sphingomyelins constitute an important class of phospholipids in the membranes of eukaryotic cells. Sphingomyelin is a sphingolipid analogue of phosphotidylcholine. It consists of a ceramide unit with a phosphorylcholine moiety attached to position one.

In most tissues, sphingomyelin content ranges from 2 to 15%. Its concentration is prominently higher in the myelin sheath protecting the nerve axons and in blood cells.

Sphingomyelin acts as a secondary messenger in cell signaling pathways. Metabolites of sphingomyelin acts as mediators in signaling cascades involved in apoptosis, proliferation and stress responses. Sphingomyelin-induced apoptosis is used in biological research to study pathways and cellular mechanisms. Sphingomyelin and its metabolite, ceramide, are also used to induce cell proliferation under laboratory conditions.

TC279 is a cell culture tested sphingomyelin.

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