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Product Identifier
| Product Name |
Poloxamer 188 |
| Specification Compliance |
Meets USP 41-NF 36, EP 9.0, BP 2016 and IP 2018 testing specification |
| Product Code |
TC222M |
Product Description
| Molecular Formula |
(C₃H₆O.C₂H₄O)x |
| CAS |
9003-11-6 |
| Synonym |
Pluronic® F-68 |
Technical Specification
| Appearance (USP) |
White, prilled or cast solid |
| Appearance (EP, BP, IP) |
White or almost white, waxy powder, microbeads or flakes |
| Solubility (USP) |
Freely soluble in water and in alcohol |
| Solubility (EP, BP) |
Soluble in water and in ethanol (96%) |
| Solubility (IP) |
Freely soluble in water and in ethanol (95%) |
| Identification A : FTIR (USP, EP, BP, IP) |
Matches with the standard pattern |
| Identification B : Average relative molecular mass (EP, BP, IP) |
7680-9510 |
| Identification C : oxypropylene to oxyethylene ratio, NMR (EP, BP, IP) |
Complies |
| Appearance of solution (EP, BP) |
10% solution in water is not more intensely coloured than reference solution BY7 |
| Appearance of solution (IP) |
10% solution in water is not more intensely coloured than reference solution BYS7 |
| pH (10% in water at 25°C) : (EP, BP, IP) |
5.00 -7.50 |
| pH (2.5% in water at 25°C): (USP) |
5.00 -7.50 |
| Average molecular weight (USP, EP, BP, IP) |
7680-9510 |
| Weight percent oxyethylene, NMR : (USP) |
79.90-83.70 |
| Unsaturation, methanolic KOH titration (USP) |
0.018 - 0.034 mEq/g |
| Oxypropylene : oxyethylene ratio, NMR (EP, BP, IP) |
Complies |
| Water (K.F.) : (EP, BP, IP) |
<= 1.00% |
| Total ash (EP, BP, IP) |
<= 0.40% |
| Heavy metals (USP) |
<= 0.0020% |
| Melting point (EP, BP) |
~50°C |
| Melting point (IP, USP) |
~52°C |
| Limit of ethylene oxide, propylene oxide and 1,4-dioxane, System suitability, resolution, GC-HS : (USP) |
min. 2.0 between ethylene oxide and propylene oxide |
| Limit of ethylene oxide, propylene oxide and 1,4-dioxane, System suitability, RSD, GC-HS: (USP) |
<= 15.00% |
| Limit of ethylene oxide, GC-HS : (EP, BP, USP, IP) |
<= 0.0001% |
| Limit of propylene oxide, GC-HS : (EP, BP, USP, IP) |
<= 0.0005% |
| Limit of dioxan, GC-HS : (EP, BP, IP) |
<= 0.0010% |
| Limit of 1,4-dioxane, GC-HS : (USP) |
<= 0.0005% |
Storage and Shelf Life
| Storage Condition |
Store below 30°C away from bright light. |
| Shelf Life |
48 months |
| Usage |
Use before expiry date given on the product label. |
CAS Number :
9003-11-6
Synonym :
Pluronic® F-68
Molecular Formula :
(C₃H₆O.C₂H₄O)x
More Information
| Product Name |
Pluronic® F-68 |
| SKU |
TC222M |
| CAS No |
9003-11-6 |
| Molecular formula |
(C₃H₆O.C₂H₄O)x |
| Synonym |
Pluronic® F-68 |