Pluronic® F-68

SKU:
TC222M
CAS Number : 9003-11-6
Synonym : Pluronic® F-68
Molecular Formula : (C₃H₆O.C₂H₄O)x
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Product Identifier

Product Name Poloxamer 188
Specification Compliance Meets USP 41-NF 36, EP 9.0, BP 2016 and IP 2018 testing specification
Product Code TC222M

Product Description

Molecular Formula (C₃H₆O.C₂H₄O)x
CAS 9003-11-6
Synonym Pluronic® F-68

Technical Specification

Appearance (USP) White, prilled or cast solid
Appearance (EP, BP, IP) White or almost white, waxy powder, microbeads or flakes
Solubility (USP) Freely soluble in water and in alcohol
Solubility (EP, BP) Soluble in water and in ethanol (96%)
Solubility (IP) Freely soluble in water and in ethanol (95%)
Identification A : FTIR (USP, EP, BP, IP) Matches with the standard pattern
Identification B : Average relative molecular mass (EP, BP, IP) 7680-9510
Identification C : oxypropylene to oxyethylene ratio, NMR (EP, BP, IP) Complies
Appearance of solution (EP, BP) 10% solution in water is not more intensely coloured than reference solution BY7
Appearance of solution (IP) 10% solution in water is not more intensely coloured than reference solution BYS7
pH (10% in water at 25°C) : (EP, BP, IP) 5.00 -7.50
pH (2.5% in water at 25°C): (USP) 5.00 -7.50
Average molecular weight (USP, EP, BP, IP) 7680-9510
Weight percent oxyethylene, NMR : (USP) 79.90-83.70
Unsaturation, methanolic KOH titration (USP) 0.018 - 0.034 mEq/g
Oxypropylene : oxyethylene ratio, NMR (EP, BP, IP) Complies
Water (K.F.) : (EP, BP, IP) <= 1.00%
Total ash (EP, BP, IP) <= 0.40%
Heavy metals (USP) <= 0.0020%
Melting point (EP, BP) ~50°C
Melting point (IP, USP) ~52°C
Limit of ethylene oxide, propylene oxide and 1,4-dioxane, System suitability, resolution, GC-HS : (USP) min. 2.0 between ethylene oxide and propylene oxide
Limit of ethylene oxide, propylene oxide and 1,4-dioxane, System suitability, RSD, GC-HS: (USP) <= 15.00%
Limit of ethylene oxide, GC-HS : (EP, BP, USP, IP) <= 0.0001%
Limit of propylene oxide, GC-HS : (EP, BP, USP, IP) <= 0.0005%
Limit of dioxan, GC-HS : (EP, BP, IP) <= 0.0010%
Limit of 1,4-dioxane, GC-HS : (USP) <= 0.0005%

Storage and Shelf Life

Storage Condition Store below 30°C away from bright light.
Shelf Life 48 months
Usage Use before expiry date given on the product label.
CAS Number : 9003-11-6
Synonym : Pluronic® F-68
Molecular Formula : (C₃H₆O.C₂H₄O)x
More Information
Product Name Pluronic® F-68
SKU TC222M
CAS No 9003-11-6
Molecular formula (C₃H₆O.C₂H₄O)x
Synonym Pluronic® F-68
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