Plot No. C40, Road No. 21Y, MIDC, Wagle Industrial Estate, Thane(W)-400604, MH, India
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Cyanocobalamin
SKU:
TC183M
CAS Number :
68-19-9
Synonym :
Vitamin B12
Molecular Formula :
C₆₃H₈₈CoN₁₄O₁₄P
Availability: In stock
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As low as
$64.50
Meets USP-NF, EP, BP, JP and IP testing specifications
CAS Number :
68-19-9
Synonym :
Vitamin B12
Molecular Formula :
C₆₃H₈₈CoN₁₄O₁₄P
Product Identifier
| Product Code | TC183M |
|---|---|
| Molecular weight | 1355.37 |
| Molecular formula | C63H88CON14O14P |
| CAS No. | 68-19-9 |
| Synonym | Vitamin B12 |
Technical Specification
| Appearance (USP) | Dark red crystals or amorphous or crystalline red powder, very hygroscopic |
|---|---|
| Appearance (EP, BP) | Dark red crystalline powder or dark red crystals, very hygroscopic |
| Appearance (IP) | Dark red crystalline powder, very hygroscopic |
| Appearance (JP) | Dark red crystals or powder, hygroscopic |
| Solubility (USP) | Soluble in alcohol; sparingly soluble in water; insoluble in acetone, in chloroform, and in ether |
| Solubility (EP, BP) | Sparingly soluble in water and in ethanol (96%), practically insoluble in acetone. |
| Solubility (JP) | It is sparingly soluble in water, and slightly soluble in ethanol (99.5%) |
| Solubility (IP) | Sparingly soluble in water and in ethanol (95%); practically insoluble in chloroform, in acetone and in ether |
| Identification A : Absorption ratio 1 : UV (USP, EP, BP, IP) | 1.70 - 1.90 (Ratio of A361/A278) |
| Identification A : Absorption ratio 2 : UV (USP) | 3.15 - 3.40 (Ratio of A361/A550) |
| Identification A, Absorption ratio 2: UV (EP, BP, IP) | 3.15 - 3.45 (Ratio of A361/A547-559) |
| Identification 1 : UV (JP) | Both spectra exhibit similar intensities of absorption at the same wavelengths |
| Identification B (USP) | A red or orange-red colour appears immediately after addition of nitroso R salt. The red colour persist after boiling with the addition of hydrochloride acid |
| Identification B, HPLC (EP, BP) | The principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution (c) |
| Identification B, TLC (IP) | The principal spot in the chromatogram obtained with the test solution corresponds to that in the chromatogram obtained with the reference solution |
| Identification 2 (JP) | The red colour does not disappear |
| Identification C (IP) | A blue colour is formed and is taken into the benzyl alcohol layer |
| Identification C, HPLC (USP) | The retention time of the major peak of the sample solution corresponds to that of the standard solution |
| Identification 3 (JP) | A blue to blue-green colour develops |
| Clarity and colour of solution (JP) | 20mg in 10 mL of water is clear and red in colour |
| pH (0.5% in water) (JP) | 4.2 - 7.0 |
| Related compounds : System suitability : Resolution : HPLC (USP) | >= 2.5 between cyanocobalmin and 7b, 8b-lactocyanocobalmin, system suitability solution |
| Related compounds : 7b, 8b-Lactocyanocobalmin : HPLC (USP) | <= 1.0% |
| Related compounds : 50-Carboxycyanocobalamin : HPLC (USP) | <= 0.5% |
| Related compounds : 32-Carboxycyanocobalamin : HPLC (USP) | <= 2.0% |
| Related compounds : 34-Methylcyanocobalmin : HPLC (USP) | <= 1.0% |
| Related compounds : 8-epi-Cyanocobalamin : HPLC (USP) | <= 1.0% |
| Related compounds : any other unidentified impurity : HPLC (USP) | <= 0.5% |
| Related compounds : Total impurity : HPLC (USP) | <= 3.0% |
| Related substances: impurity C : HPLC (EP, BP) | <= 1.5% |
| Related substances: impurity A : HPLC (EP, BP) | <= 0.7% |
| Related substances: impurity B, D, E, F: for each impurity: HPLC (EP, BP) | <= 0.5% |
| Related substances: unspecified impurities: for each impurity: HPLC (EP, BP) | <= 0.2% |
| Related substances: Total impurity : HPLC (EP, BP) | <= 3.0% |
| Related substances: HPLC (JP) | The total area of the peak other than cyanocobalamin obtained from the sample solution is not larger than the peak area of cyanocobalamin from the standard solution |
| Related substances: HPLC (IP) | The sum of the areas of all the secondary peaks is not more than the area of the principal peak in the chromatogram obtained with reference solution (a). Ignore any peak with an area less than that of the principal peak in the chromatogram obtained with reference solution (b). |
| Loss on drying (at 105°C, 2 hr) (USP) | <= 12.0% (at pressure <= 5 mm of mercury) |
| Loss on drying (at 105°C, 2 hr) (EP, BP) | <= 12.0% (0.4g by drying in vacuo) |
| Loss on drying (at 105°C, 2 hr) (IP) | <= 12.0% (at pressure of 1.5 - 2.5 kpa) |
| Loss on drying (at 100°C, 4 hr) (JP) | <= 12% (at pressure not exceeding 0.67 kPa, phosphrous (V) oxide) |
| Assay (UV, on dried basis) (USP, EP, BP, JP, IP) | 96.0 - 102.0% |
Storage and Shelf Life
| Storage | Store at 2 - 8°C away from bright light. |
|---|---|
| Shelf life | 36 months. |
| Use before | expiry date given on the product label. |
CAS Number :
68-19-9
Synonym :
Vitamin B12
Molecular Formula :
C₆₃H₈₈CoN₁₄O₁₄P
| Product Name | Cyanocobalamin |
|---|---|
| SKU | TC183M |
| CAS No | 68-19-9 |
| Molecular formula | C₆₃H₈₈CoN₁₄O₁₄P |
| Molecular Weight | 1355.37 |
| Synonym | Vitamin B12 |
| Storage | Store at 2 - 8°C away from bright light. |
| Shelf Life | 3 Years |
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