L-Serine

SKU:
TC113M
CAS Number : 56-45-1
Molecular Formula : C₃H₇NO₃
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Product Identifier

Product Name L-Serine (From non-animal source)
Product Code TC113M
Molecular Weight 105.09
Molecular Formula C₃H₇NO₃
CAS No. 56-45-1
Shelf life 48 months

Storage Information

Store below 30°C away from bright light. Use before expiry date given on the product label.

Technical Specification

Meets Specification USP-NF, EP, JP and BP testing specification
Appearance (USP) White crystals
Appearance (EP, BP) White or almost white, crystalline powder or colourless crystals
Appearance (JP) White, crystals or a crystalline powder
Solubility (USP) Soluble in water; practically insoluble in absolute alcohol and in ether
Solubility (EP, BP) Freely soluble in water, practically insoluble in ethanol (96%)
Solubility (JP) Freely soluble in water and in formic acid, and practically insoluble in ethanol (99.5). It dissolves in 2 mol/L hydrochloric acid TS
pH (10% in water at 25°C) : (JP) 5.20 - 6.20
Identification: FTIR (JP) Matches with the standard pattern
Identification A : FTIR (USP) Matches with the standard pattern
Identification A : Specific rotation (EP, BP) +14.00° to +16.00° (10% in dilute hydrochloric acid R 20 ± 0.5°C, dried substance)
Identification B: FTIR (EP, BP) Matches with the standard pattern
Identification C: TLC (EP, BP) The principal spot in the chromatogram obtained with test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with reference solution
Identification D (EP, BP) A violet-red colour is produced
Appearance of the solution (EP, BP) 5% solution in water is clear and not more intensely coloured than reference solution BY 6
Clarity and color of solution (JP) 10% solution in water is clear and colourless
Chloride (USP) <= 0.05%
Chloride (EP, BP) <= 0.02%
Chloride (JP) <= 0.021%
Ammonium (JP) <= 0.02%
Ammonium : Amino acid analysis (EP,BP) <= 0.02%
Heavy metals (JP) <= 0.001%
Iron (USP) <= 0.003%
Iron (JP, EP, BP) <= 0.0010%
Sulphate (JP) <= 0.028%
Sulphate (USP, EP, BP) <= 0.03%
Optical rotation (JP) +14.00° to +16.00° (10% in 2 mol/L hydrochloric acid TS at 20°C)
Specific rotation : (EP, BP) +14.00° to +16.00° (10% in dilute hydrochloric acid R 20 ± 0.5°C, dried substance)
Specific rotation (USP) +14.00° to +15.60° (c='10% in 2N hydrochloric acid at 25°C)
Loss on drying (JP) <= 0.30% (at 105°C, 3 hr)
Loss on drying (USP) <= 0.20% (at 105°C, 3 hr)
Loss on drying (BP, EP) <= 0.50% (at 105°C, 2 hr)
Residue on ignition (JP, USP) <= 0.10%
Sulfated ash (EP, BP) <= 0.10%
Related substances : TLC (JP) The spot other than the principal spot obtained from the sample solution is not more intense than the spot obtained from the standard solution
Ninhydrin-positive substances : system suitability : Amino acid analysis : resolution (EP, BP) min.1.5 between the peaks due to isoleucine and leucine
Ninhydrin-positive substances : any ninhydrin-positive substance, for each impurity : Amino acid analysis (EP, BP) <= 0.20%
Ninhydrin-positive substances : total impurity : Amino acid analysis (EP, BP) <= 0.50%
Related compounds : TLC (USP) Any secondary spot of the sample solution is not larger or more intense than the principal spot of the standard solution
Related compounds : Individual impurities : TLC (USP) <= 0.50%
Related compounds : Total impurities: TLC (USP) <= 2.00%
Assay (NT, dried basis) : (USP) 98.50 - 101.50%
Assay (NT, dried substance) : (EP, BP, JP) 98.50 - 101.00%
CAS Number : 56-45-1
Molecular Formula : C₃H₇NO₃
More Information
Product Name L-Serine
SKU TC113M
CAS No 56-45-1
EC No. 200-274-3
Molecular formula C₃H₇NO₃
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