Freely soluble in water, very slightly soluble in alcohol and in ether
Solubility (EP, BP)
Freely soluble in water, very slightly soluble in ethanol (96%)
Solubility (IP)
Freely soluble in water, very slightly soluble in ethanol (95%), Practically insoluble in ether
Solubility (JP)
Freely soluble in water and in formic acid and practically insoluble in ethanol (95%)
pH (5% in water at 25°C) (EP, BP)
5.90 - 6.40
pH (5% in water at 25°C) (JP)
5.60 - 6.60
pH (5% in water at 25°C) (IP)
5.90 - 6.30
Identification : FTIR (JP)
Matches with the standard pattern
Identification A : FTIR (USP, EP, BP, IP)
Matches with the standard pattern
Identification B : TLC (EP, BP)
The principal spot in the chromatogram obtained with test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with reference solution
Identification B (IP)
The resulting solution is violet with greenish-yellow fluorescence. After a few minutes, the colour becomes orange and then yellow and an intense fluorescence remains
Identification C (EP, BP)
The solution is violet with greenish-yellow fluorescence. After a few minutes, the colour becomes orange and then yellow and an intense fluorescence remains.
Appearance of solution (EP, BP)
10% solution in water is clear and not more intensely coloured than reference solution Y7
Appearance of solution (IP)
10% solution in water is clear and not more intensely coloured than reference solution YS7
Clarity and color of solution (JP)
10% solution in water is clear and colorless
Chloride (JP)
<= 0.021%
Chloride (USP)
<= 0.007%
Chloride (EP, BP)
<= 0.0075%
Chloride (IP)
<= 0.01%
Ammonium (Amino acid analysis) : (EP, BP)
Complies
Ammonium (JP)
<= 0.02%
Sulfate (USP)
<= 0.0065%
Sulfate (JP)
<= 0.028%
Heavy metals (JP)
<= 0.0020%
Heavy metals (IP)
<= 0.0010%
Arsenic (JP)
<= 0.0002%
Residue on ignition (USP, JP)
<= 0.10%
Loss on drying (USP)
<= 0.20% (at 105°C, 2 hr)
Loss on drying (EP, BP, IP)
<= 0.50% (at 105°C, 2 hr)
Loss on drying (JP)
<= 0.30% (at 105°C, 3 hr)
Sulfated ash (EP, BP, IP)
<= 0.10%
Hydrolyzable substances (USP)
The solution appears as clear and as mobile as 10 mL of the same solution that has not been boiled