L-Cystine

SKU:
TC070M
CAS Number : 56-89-3
Molecular Formula : C₆H₁₂N₂O₄S₂
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Product Identifier

Product Name L-Cystine (From non-animal source)
Product Code TC070M
Molecular weight 240.30
Molecular formula C6H12N2O4S2
CAS No. 56-89-3

Technical Specification

Appearance (EP, BP) White or almost white, crystalline powder
Appearance (JP) White crystals or crystalline powder
Solubility (BP, EP) Practically insoluble in water and in alcohol (96%). It dissolves in dilute solutions of alkali hydroxides
Solubility (JP) Practically insoluble in water and in ethanol (99.5%). It dissolves in 1 mol/L hydrochloric acid TS.
Identification 1 : FTIR (JP) Both spectra exhibit similar intensities of absorption at the same wave numbers
Identification A : FTIR (USP) Matches with the standard pattern
Identification A : Specific rotation (EP, BP) -224.00 to -218.00° (c= 2% in 1M HCl acid at 20 ± 0.5°C, dried substance)
Identification B : Specific rotation (USP) -225.00° to -215.00° (c= 2% in 1N hydrochloric acid at 20°C, perform the measurements immediately after preparation)
Identification B : FTIR (EP, BP) Matches with the standard pattern
Identification C : TLC (USP) The Rf value of the principal spot of the sample solution in the test for organic impurities corresponds to that of the standard solution
Identification C : TLC (BP, EP) The principal spot in the chromatogram obtained with test solution (b) is similar in position, colour and size to the principal spot in the chromatogram obtained with reference solution (a).
Identification D : (EP, BP) Turbidity or a white precipitate develops within 3 min
Appearance of solution (EP, BP) 10% solution in dilute hydrochloric acid R is clear and not more intensely coloured than reference solution Y7
Clarity and color of solution : (JP) 10% solution in 2M hydrochloric acid TS is clear and colorless
Specific rotation (EP, BP) -224.00 to -218.00° (c = 2% in 1M HCl acid at 20 ± 0.5°C, dried substances)
Specific rotation (USP) -225.00° to -215.00° (c = 2% in 1N hydrochloric acid at 20°C)
Specific rotation (JP) -225.00° to -215.00° (c = 2% in 1M hydrochloric acid at 20°C, after drying)
Ammonium : Amino acid analysis (EP) <= 0.02%
Ammonium: (JP, BP) <= 0.02%
Iron (USP, EP, BP, JP) <= 0.0010%
Sulfate (USP) <= 0.02%
Sulfate (JP) <= 0.028%
Sulfate (EP, BP) <= 0.03%
Chloride (USP, EP, BP) <= 0.02%
Chloride (JP) <= 0.021%
Heavy metals (USP, JP, BP) <= 0.0010%
Loss on drying (at 105°C, 2h) : (EP, BP) <= 0.50%
Loss on drying (at 105°C, 3h) : (USP) <= 0.20%
Loss on drying (at 105°C, 3h) : (JP) <= 0.30%
Residue on ignition (USP, JP) <= 0.10%
Sulfated ash (EP, BP) <= 0.10%
Organic impurities 1 : Individual impurities, TLC (USP) <= 0.20%
Organic impurities 2 : Total impurities, TLC (USP) <= 2.00%
Ninhydrin-positive substances, system suitability : Resolution, Amino acid analysis (EP) >= 1.50 between the peaks due to isoleucine and leucine
Ninhydrin-positive substances 1 : for each impurity, Amino acid analysis (EP) <= 0.20%
Ninhydrin-positive substances 2 : total impurities, Amino acid analysis (EP) <= 0.50%
Ninhydrin-positive substances, TLC : (BP) Complies
Assay (Iodometry, dried substance): (EP, BP) 98.50 - 101.00%
Assay (Iodometry, dried basis): (USP) 98.50 - 101.50%
Assay (Nitrogen, dried basis): (JP) 99.00 - 101.00%
Storage Store below 30°C.
Shelf life 48 months.
CAS Number : 56-89-3
Molecular Formula : C₆H₁₂N₂O₄S₂
More Information
Product Name L-Cystine
SKU TC070M
CAS No 56-89-3
EC No. 200-296-3
Molecular formula C₆H₁₂N₂O₄S₂
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