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L-Cysteine hydrochloride monohydrate
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Availability: In stock
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SKU:
TC058
CAS Number :
7048-04-6
Molecular Formula :
C₃H₇NO₂S.HCl.H₂O
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Product Identifier
| Product Name | L-Cysteine hydrochloride monohydrate |
|---|---|
| SKU | TC058 |
| Molecular Weight | 175.64 |
| Molecular Formula | C₃H₇NO₂S.HCl.H₂O |
| CAS No | 7048-04-6 |
| Source | Non-animal source |
| Cell Culture Grade | Tested |
| Shelf life | 36 months |
Technical Specification
| Description |
It is a non-essential α-amino acid, chemically polar in nature, coded by codons UGU and UGC. It is one of the two sulfur containing amino acids. Because of presence of thiol group (-SH) it is less toxic and acts as an anti-oxidant to prevent free radical generation. It is used as a major component in wide range of cell culture media including classical and serum-free media. It plays many roles in cell culture systems. Some of them are mentioned below: 1. Substrate for protein synthesis: Thiol group present in the structure of cysteine play important role in formation of disulfide linkages. It is also responsible for protein folding and generation of secondary and tertiary structures of protein. Cystine, the oxidation product participates in numerous posttranslational modifications. 2. Synthesis of enzyme acetyl CoA. 3. Protection of cells from oxidative stress: L-cysteine participates as a rate limiting enzyme in synthesis of glutathione. Glutathione catalyses conversion of dehydroascorbic acid to ascorbis acid, which ultimately serves as an effective anti-oxidant and prevents lipid peroxidation. L-cysteine is metabolized by many cells to produce hypotaurine and taurine. These two molecules help detoxify the culture media by reacting with free hydroxyl groups and hypochlorous acid generated the media. 4. Source of sulfur: L-cysteine acts as a major source of sulfur in cell culture. 5. Reservoir for cysteine derivatives: Oxidation of thiol group of cysteine leads to formation of cystine. Unpaired protein cysteine sulfhydryls can react with a free cysteine sulfhydryl to form mixed disulfides. These disulfides act as a storage and transport reservoir for cysteine equivalents. 6. Metal ion carrier: Thiol group in cysteine has affinity for metal ions such as iron, zinc, nickel, copper etc. This property makes it useful in transport of metal-ion linked molecules (such as cytochrome) across the cell membrane. |
|---|---|
| Directions | L-Cysteine hydrochloride monohydrate is soluble in water. |
| Appearance | White crystals or crystalline powder. |
| Solubility (QC) | Clear colorless solution at 10gm in 100ml of water. |
| pH of 1% solution in water | 1.50-2.00 |
| Specific rotation [alpha]20/D | +6.1° to +7.8° |
| Chloride (Cl) | 19.89 to 20.29% |
| Ammonium (NH4) | <= 0.02% |
| Sulphate (SO4) | <= 0.02% |
| Iron (Fe) | <= 0.001% |
| Heavy metals (Pb) | <= 0.001% |
| Arsenic (As) | <= 0.0001% |
| Residue on ignition | <= 0.1% |
| Loss on drying | 8.5 to 12.0% |
| Other amino acids | Conforms |
| Assay | NLT 98.5% |
| Cell Culture Test | Passes |
| Storage Conditions | Store at 10-30°C away from bright light. |
| Stability Notes | Aqueous solutions L-Cysteine hydrochloride monohydrate get oxidized to cystine when exposed to air. Presence of heavy metals (such as copper and iron) accelerate the oxidation process. Neutral or alkaline pH also contributes to oxidation. Solutions are relatively stable at acidic pH. |
| Usage Instruction | Use before expiry date given on the product label. |
CAS Number :
7048-04-6
Molecular Formula :
C₃H₇NO₂S.HCl.H₂O
| Product Name | L-Cysteine hydrochloride monohydrate |
|---|---|
| SKU | TC058 |
| CAS No | 7048-04-6 |
| EC No. | 200-157-7 |
| Molecular formula | C₃H₇NO₂S.HCl.H₂O |
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