CF013 is recombinant murine G-CSF expressed in E. coli, filtered through 0.22μ membrane filter and lyophilized. Granulocyte Colony Stimulating Factor (G-CSF) is a proliferation, differentiation, survival and activation factor of hematopoietic cells of the restricted neutrophil granulocyte lineage.
Granulocyte Colony Stimulating Factor (G-CSF) is a proliferation, differentiation, survival and activation factor of hematopoietic cells of the restricted neutrophil granulocyte lineage. It is a powerful stimulator of mature human eosinophils and neutrophils. It binds to the transmembrane receptor G-CSFR (also called CD114) and induces intracellular signals. Although G-CSF is relatively specific for cells belonging to the neutrophil lineage, at higher concentrations it also has some effect on multi- progenitor cells.