Human Recombinant Bone morphogenetic protein-13 Source : E.coli Cell Culture Tested

Bone Morphogenetic Proteins (BMPs) for a unique group of proteins within Transforming Growth factor - β (TGF-β) superfamily. BMPs play a role in differentiation, proliferation, growth inhibition and arrest of maturation of a wide variety of cells depending on the cellular microenvironment and the interactions with other regulatory factors. They also play important role in the process of bone modeling-remodeling, bone and cartilage formation. BMPs induce signals through 3 types of transmembrane receptors namely BMPR1A, BMPR1B and BMPR2. In cell culture applications, BMPs are important regulators of stem cell differentiation, maintenance, reprogramming and self-renewal, as well as carcinogenesis suppression. They bind to their cell surface receptors on mesenchymal stem cells and send signals to the cell nucleus which results in the synthesis of macromolecules involved in cartilage and bone formation and then the mesenchymal cell differentiates into chondrocytes or osteoblasts. BMP-13 plays important role in the growth and maintenance of articular cartilage.