Nystatin Suspension w/ 10,000units Nystatin per ml in Dulbecco’s Phosphate Buffered Saline

Nystatin is a polyene antifungal agent effective against molds and yeasts, including Candida. It was originally extracted from bacteria Streptomyces noursei in 1950. Like amphotericin B, nystatin also binds with ergosterol, a major component of fungal cell membrane, forming pores in the membrane. The resultant loss of cations (e.g. K+, Na+, H+), and/or other low molecular weight substances including sugars, amino acids or nucleotides, the increase or amplification of Na2+/K+ pump activity in addition to the inhibitory effect through these channels in the extracellular space of several membrane bound enzymes collectively lead to fungal death. Ergosterol is unique to fungi, so the drug does not have any adverse effect on animal cells.