Did you know that your Gut feeling depends on a lot of factors?

Let's begin by getting to know the human microbiome better! It composes of bacteria, archaea, viruses and eukaryotic microbes that reside in and on our bodies. It typically comprises of the genetic material within a microbiota. The microbiome is important for maintaining human health, and when things go wrong, it can contribute to a disease. These microbes have tremendous potential to impact our physiology, both in health and during sickness.

Microbes that reside in the human gut are key contributors of metabolic functions and they protect the immune system. Through these basic functions, also they affect our physiologic functions directly or indirectly. [more info 1] [more info 2]

The gut microbiome acts as a barrier against harmful microbes by competing for nutrients, ecological binding site occupancies and production of antimicrobial substances. Numerous antimicrobial compounds, such as defensins, cathelicidins and C-type lectins, are produced by microbes in the GI tract. The presence of commensal bacteria or their structural components have the capacity to protect the gut from invading pathogens and preventing the overgrowth of the

commensals themselves. Induction can be mediated through various signalling pathways.

What's the equation between the Gut Microbiome and Antibiotic like? We show an antibiotic and a gut microbiome hanging out together.
In healthy individuals, the microbiome and host have a mutual relationship in which both partners benefit. However, pathogens may invade and cause diseases under certain conditions. Although, antibiotics fight bacterial pathogens and can cure life-threatening infectious diseases, improper use can easily create an imbalance in microbiota in the gut. Thus, antibiotic is considered as bilateral tool since they have side effects on human health. An unbalanced microbiota in the gut is also a contributing factor in autoimmunity. The destruction of healthy gut flora can make the mucosal lining more susceptible to leakage, which some researchers believe is a precondition for developing autoimmunity.

The importance of a healthy gut microbiome extends beyond the gut. Microbes may also play a role in many activities taking place outside the gut, such as brain-gut interactions, for example, influencing the host's response to stress.
Additionally, microbial products such as acetate, can travel across the intestinal and blood-brain barrier to interact with areas of the brain that help control appetite. [more info]

Humans and microbes depend on one another : our bodies provide microbes with resources, and the microbes provide functions necessary for our health. Hence, the microbiome has received increasing attention over the last 15 years. Although gut microbes have been explored for several decades, investigations of the role of microorganisms that reside in the human gut have attracted much attention beyond classical infectious diseases. In fact, environmental factors such as dietary habits, drug treatments, intestinal motility and stool frequency and consistency are all factors that influence the composition of the microbiota and should be considered while further research.

Any such in-depth research in microbiome needs well authenticated reference standards to validate the procedures we use in Microbiome studies and to direct us. Towards this ATCC has designed and developed Microbiome standards after 2 decades of extensive research. ATCC Microbiome Standards are fully sequenced, characterized, and authenticated mock microbial communities that mimic mixed metagenomics samples. Each community is prepared from authenticated strains that have been selected for relevant phenotypic and genomic attributes.

The robust applicability of these controls, combine with ATCC's commitment to authentication and characterization, make ATCC Microbiome Standards the ideal tool for standardizing data from a wide range of sources and generating consensus among microbiome applications and analyses. [more info]

HiMedia, being official distributor of all ATCC products, would be happy to make these standards available for microbiome research. [more info]